The teaching and learning research programme (TLRP) in Wales: research evidence for educational policy and practice in Wales

Alex Morgan and Jane Waters, Swansea University; Jane Williams

Race and Socioeconomic Factors Affect Opportunities for Better Health

Examines racial/ethnic disparities in mortality and diabetes rates and the links between income and health within and across groups. Explores how race/ethnicity affects income at a given education level or socioeconomic conditions at a given income level

Shifting the culture and design of complaints systems: Participation, reflexivity and ethics

This thesis comprises of a critical appraisal evaluating the collective contribution to knowledge of six of my peer reviewed publications in relation to how participatory, reflexive and ethical approaches to complaints can create a complaint systems culture that supports all actors affected by complaints and ensure greater accountability for learning. By adopting a constructionist approach to complaints, the appraisal draws attention to the negativity associated with complaints and the tension within complaints handling where parties to the disputes have different versions of truth and subjectivity and perspectivism play a part. Using a lens informed by critical theory and reflexivity, key learnings generated from these publications relate to the impact of power asymmetries on complaints including institutionalisation and gender. The critical appraisal goes on to develop a conceptual framework that situates complaints within conditions of power, subjectivity and underpinning values and highlights the importance of participation, reflexivity and ethics in giving agency to the parties affected by complaints. It argues that this can lead to greater accountability for learning, recognising that resolving complaints can involve different perspectives, multiple and complex issues and the answer is unlikely to be binary. Implications for practice include the fact that that the framework is a firm reminder of the role that consumer ADR, complaint systems and complaint handlers have in addressing power differentials. Further, that in order to facilitate participation, reflexivity and ethics complaint system designers may require collaborative approaches qualitatively different than some complaint systems in the UK currently accommodate

Hybrid and Internationalized Criminal Tribunals: Jurisdictional Issues

In recent years a number of criminal tribunals have been established to investigate, prosecute and try individuals accused of serious violations of international humanitarian law and international human rights. These tribunals have been described as 'hybrid' or 'internationalised' tribunals as their structure and applicable law consist of both international and national elements. Six such tribunals are currently in operation: the Special Court for Sierra Leone, the Extraordinary Chambers in the Courts of Cambodia, Regulation 64 panels in Kosovo, the War Crimes Chamber for Bosnia and Herzegovina, the Iraqi High Tribunal and the Special Tribunal for Lebanon. The key aims of this thesis are: to examine the increasing role of hybrid and internationalised judicial institutions in prosecuting international crimes; to outline the basic features of the existing and proposed hybrid or internationalized tribunals; to define and categorise the tribunals; to determine the jurisdictional basis of each tribunal; to analyze how the jurisdictional basis affects other issues, such as the applicable law, the application of amnesties and immunities and the relationship of these tribunals with the host state, third states, national courts and other international criminal tribunals

Lc3i And Lc3ii As Autophagy Markers For The Development And Improvement Of Products And Techniques Used In Research

Abstract LC3I and LC3II as Autphagy Markers for the Development and Improvement of Products and Techniques used in Research By Caitlin J. Williams May 2013 Advisor: Dr. Robert Akins Major: Biochemistry & Molecular Biology Degree: Master of Science Autophagy is an intracellular process that functions to maintain homeostasis in the cell by degrading misfolded proteins, old or nonfunctioning organelles, and outside invaders such as bacteria or viruses. This process can be split into three different types, microautophagy, chaperone mediated autophagy and macroautophagy. Macroautophagy is the most commonly studied form and is believed to be regulated by Atg proteins, as well as cargo proteins that bring debris to the autophagosome. Macroautophagy is characterized by 5 steps including initiation, elongation, maturation, autophagosome-lysosome fusion and lysosome degradation. Autophagy has been found to be involved in diseases, such as cancer and neurological disease. LC3I and LC3II function in late stage autophagy before lysosome fusion. The study of a complex process such as autophagy requires the development of tools to enable precise and quantitative research. The ability to produce antibodies to key autophagy proteins, methods of cellular fractionation and fractionated control cell lysates provides product development opportunities for Enzo Life sciences and new research tools for researchers. To support these needs, methods of cell fractionation were developed along with antibodies specific to LC3I and LC3II. Cell fractionation methods were optimized to enable separation of LC3I and LC3II. The optimized methods were shown to be effective on multiple cell lines with the use of western blotting. Due to the difficulty in achieving stable hybridomas monoclonal 39 antibodies that bind both LC3I and LC3II haven\u27t been identified. The LC3II antibody development failed to produce antibodies in western blotting. Efforts are ongoing to identify stable hybridomas producing antibodies to LC3. The antibodies should recognize both LC3I and II. Combining the use of these antibodies with fractionated cell lysate methodology should allow quantitative detection of LC3II by ELISA. Such a tool will be an important tool for autophagy researchers